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Comment
. 2018 Jul:73:70-71.
doi: 10.1016/j.ceca.2018.04.002. Epub 2018 Apr 18.

GRAM marks the spot for STIM. Commentary on "GRAM domain proteins specialize functionally distinct ER-PM contact sites in human cells"

Paula Nunes  1 , Nicolas Demaurex  2
Affiliations
Comment

GRAM marks the spot for STIM. Commentary on "GRAM domain proteins specialize functionally distinct ER-PM contact sites in human cells"

Paula Nunes et al. Cell Calcium. 2018 Jul.

Abstract

GRAM domain proteins were reported as novel ER-PM tethers defining specific membrane contact sites (MCS) subdomains. GRAMD2a pre-marks the sites occupied by STIM1 at MCS and its ablation impairs STIM1 translocation, but not store-operated Ca2+ entry. We discuss these apparently counterintuitive findings in the context of STIM/ORAI signaling at MCS.

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