Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1978 Sep;64(1):6-8.
doi: 10.1111/j.1476-5381.1978.tb08633.x.

Sulphasalazine is a potent inhibitor of prostaglandin 15-hydroxydehydrogenase: possible basis for therapeutic action in ulcerative colitis

J R Hoult, P K Moore

Sulphasalazine is a potent inhibitor of prostaglandin 15-hydroxydehydrogenase: possible basis for therapeutic action in ulcerative colitis

J R Hoult et al. Br J Pharmacol. 1978 Sep.

Abstract

Sulphasalazine is a potent and selective inhibitor in vitro of prostaglandin 15-hydroxydehydrogenase in rabbit colon (ID50 = 50 micrometer) and in several other organs of different species, but does not inhibit prostaglandin delta-13 reductase or microsomal prostaglandin synthesis from arachidonic acid. It is suggested that this action may underly the therapeutic usefulness of sulphasalazine in ulcerative colitis for the prevention of relapse.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Adv Prostaglandin Thromboxane Res. 1976;2:547-55 - PubMed
    1. Lancet. 1965 Jan 23;1(7378):188-9 - PubMed
    1. N Engl J Med. 1975 Jul 3;293(1):20-3 - PubMed
    1. Pharmacol Rev. 1974 Mar;26(1):33-67 - PubMed
    1. Prostaglandins. 1974 Jul 10;7(1):1-10 - PubMed

Substances

LinkOut - more resources