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Clinical Trial
. 1988 Apr 23;17(15):719-22.

[Systematic inhibition of the luteinizing hormone with a gonadoliberin analog, triptorelin, during ovarian stimulation for fertilization in vitro. Choice of protocol]

[Article in French]
P Fenichel  1 , M Grimaldi, S Hieronimus, J F Olivero, A Donzeau, B Benoit, M Fiorentini, D K Tran, M Harter, J Y Gillet
Affiliations
  • PMID: 2968548
Clinical Trial

[Systematic inhibition of the luteinizing hormone with a gonadoliberin analog, triptorelin, during ovarian stimulation for fertilization in vitro. Choice of protocol]

[Article in French]
P Fenichel et al. Presse Med. .

Abstract

The quality of ovarian stimulation for in vitro fertilization with or without an LH-RH analogue was investigated in a randomized trial involving 30 women divided into 3 groups. Group I women were treated with the conventional clomiphene citrate-human menopausal gonadotropin combination without LH-RH analogue. Group II women (long regimen) received a slow-release preparation of triptorelin (DTRp6-LH-RH), an LH-RH analogue, and human menopausal gonadotropin. Group II women (short regimen) were given triptorelin with human menopausal gonadotropin. Inhibition of the endogenous luteinizing hormone using triptorelin improved the results of in vitro fertilization in group II and group III women, but the short regimen was distinctly less compelling and less expensive than the long regimen.

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