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Observational Study
. 2018 Jun;32(6):545-549.
doi: 10.1016/j.jdiacomp.2018.03.015. Epub 2018 Apr 4.

Mortality in youth-onset type 1 and type 2 diabetes: The SEARCH for Diabetes in Youth study

Kristi Reynolds  1 , Sharon H Saydah  2 , Scott Isom  3 , Jasmin Divers  4 , Jean M Lawrence  5 , Dana Dabelea  6 , Elizabeth J Mayer-Davis  7 , Giuseppina Imperatore  8 , Ronny A Bell  9 , Richard F Hamman  10
Affiliations
Observational Study

Mortality in youth-onset type 1 and type 2 diabetes: The SEARCH for Diabetes in Youth study

Kristi Reynolds et al. J Diabetes Complications. 2018 Jun.

Abstract

Aims: To estimate short-term mortality rates for individuals with type 1 or type 2 diabetes diagnosed before age 20 years from the SEARCH for Diabetes in Youth study.

Methods: We included 8358 individuals newly-diagnosed with type 1 (n = 6840) or type 2 (n = 1518) diabetes from 1/1/2002-12/31/2008. We searched the National Death Index through 12/31/2010. We calculated standardized mortality ratios (SMRs) based on age, sex, and race for the comparable US population in the geographic areas of the SEARCH study.

Results: During 44,893 person-years (PY) of observation (median follow-up = 5.3 years), 41 individuals died (91.3 deaths/100,000 PY); 26 with type 1 (70.6 deaths/100,000 PY) and 15 with type 2 (185.6 deaths/100,000 PY) diabetes. The expected mortality rate was 70.9 deaths/100,000 PY. The overall SMR (95% CI) was 1.3 (1.0, 1.8) and was high among individuals with type 2 diabetes 2.4 (1.3, 3.9), females 2.2 (1.3, 3.3), 15-19 year olds 2.7 (1.7,4.0), and non-Hispanic blacks 2.1 (1.2, 3.4).

Conclusions: Compared to the state populations of similar age, sex, and race, our results show excess mortality in individuals with type 2 diabetes, females, older youth, and non-Hispanic blacks. We did not observe excess short-term mortality in individuals with type 1 diabetes.

Keywords: Epidemiology; Mortality; Type 1 Diabetes; Type 2 Diabetes; Youth.

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Conflict of interest statement

Declarations of Interest. No potential conflicts of interest relevant to this article were reported.

Figures

Figure 1
Figure 1
Age-, Sex-, and Race-Standardized Mortality Ratios Overall and by Diabetes Type, Sex, Race/Ethnicity, and Age at Death or End of Follow-up
See this image and copyright information in PMC

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