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Case Reports
. 2018 Jan 3;31(1):88-89.
doi: 10.1080/08998280.2017.1400300. eCollection 2018 Jan.

Chronic neutrophilic leukemia

Arthur Bredeweg  1 , Micah Burch  1 , John R Krause  1
Affiliations
Case Reports

Chronic neutrophilic leukemia

Arthur Bredeweg et al. Proc (Bayl Univ Med Cent). .

Abstract

Chronic neutrophilic leukemia is a rare myeloproliferative disorder characterized by a sustained peripheral blood neutrophilia, absence of the BCR/ABL oncoprotein, bone marrow hypercellularity with less than 5% myeloblasts and normal neutrophil maturation, and no dysplasia. This leukemia has been associated with mutations in the colony-stimulating factor 3 receptor (CSF3R) that may activate this receptor, leading to the proliferation of neutrophils that are the hallmark of chronic neutrophilic leukemia. We present a case of chronic neutrophilic leukemia and discuss the criteria for diagnosis and the significance of mutations found in this leukemia.

Keywords: CSF3R; Chronic neutrophilic leukemia; RUNX1; SETBP1; SRSF2; myeloproliferative disorder.

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Figures

Figure 1.
Figure 1.
(a) Peripheral blood (Wrights, ×500). (b) Bone marrow aspirate (Wrights, ×500). (c) Bone marrow core biopsy (hemotoxylin and eosin, ×400).
See this image and copyright information in PMC

References

    1. Arber DA, Orazi A, Hasserjian R, et al.. The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood. 2016;127(20):2391–2405. doi:10.1182/blood-2016-03-643544. - DOI - PubMed
    1. Pardanani A, Lasho TL, Laborde RR, et al.. CSF3R T618I is a highly prevalent and specific mutation in chronic neutrophilic leukemia. Leukemia. 2013;27(9):1870–1873. doi:10.1038/leu.2013.122. - DOI - PMC - PubMed
    1. Maxson JE, Gotlib J, Pollyea DA, et al.. Oncogenic CSF3R mutations in chronic neutrophilic leukemia and atypical CML. N Engl J Med. 2013;368(19):1781–1790. doi:10.1056/NEJMoa1214514. - DOI - PMC - PubMed
    1. Gotlib J, Maxson JE, George TI, Tyner JW. The new genetics of chronic neutrophilic leukemia and atypical CML: implications for diagnosis and treatment. Blood. 2013;122(10):1707–1711. doi:10.1182/blood-2013-05-500959. - DOI - PMC - PubMed
    1. Cui Y, Li B, Gale RP, et al.. CSF3R, SETBP1 and CALR mutations in chronic neutrophilic leukemia. J Hematol Oncol. 2014;7(1):77–81. doi:10.1186/s13045-014-0077-1. - DOI - PMC - PubMed

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