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Case Reports
. 2018 Feb 23;4(3):232-234.
doi: 10.1016/j.jdcr.2017.11.019. eCollection 2018 Apr.

Pathogenesis-based therapy: Cutaneous abnormalities of CHILD syndrome successfully treated with topical simvastatin monotherapy

Sultan Mohammad Bajawi  1 , Sultan Aqeel Jafarri  1 , Mohammed Ali Buraik  1   2 , Khalid Mohammed Al Attas  1 , Hasan Yehia Hannani  1
Affiliations
Case Reports

Pathogenesis-based therapy: Cutaneous abnormalities of CHILD syndrome successfully treated with topical simvastatin monotherapy

Sultan Mohammad Bajawi et al. JAAD Case Rep. .
No abstract available

Keywords: CHILD syndrome; CHILD, congenital hemidysplasia, ichthyosiform nevus, and limb defects; congenital; ichthyiosis; pathogenesis; simvastatin.

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Figures

Fig 1
Fig 1
Cutaneous abnormalities of CHILD syndrome before treatment. A, Ipsilateral ichthyosiform plaques over right pectoralis region, axillae, and shoulder with a sharp midline demarcation and ptychotropism. Note missing right upper limb. B, CHILD nevus following Blaschko lines.
Fig 2
Fig 2
Histopathologic examination (hematoxylin-eosin stain) shows psoriasiform dermatitis with acanthosis, zones of parakeratosis, and an exocytosis of neutrophils.
Fig 3
Fig 3
Cutaneous abnormalities of CHILD syndrome after treatment. A, Dramatically responded to topical application of simvastatin with only postinflammatory hypopigmentation after 6 weeks. B, Showing sustained improvement after 10 months of maintenance treatment.
See this image and copyright information in PMC

References

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    1. Happle R., Koch H., Lenz W. The CHILD syndrome. Congenital hemidysplasia with ichthyosiform erythroderma and limb defects. Eur J Pediatr. 1980;134:27–33. - PubMed
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