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Review
. 2019 Mar;3(1):21-30.
doi: 10.1007/s41669-018-0076-1.

Systematic Review of Economic Models Used to Compare Techniques for Detecting Peripheral Arterial Disease

Eoin Moloney  1 , Joanne O'Connor  2 , Dawn Craig  2 , Shannon Robalino  3 , Alexandros Chrysos  2 , Mehdi Javanbakht  2 , Andrew Sims  4   5 , Gerard Stansby  6 , Scott Wilkes  7 , John Allen  4   8
Affiliations
Review

Systematic Review of Economic Models Used to Compare Techniques for Detecting Peripheral Arterial Disease

Eoin Moloney et al. Pharmacoecon Open. 2019 Mar.

Abstract

Background and objective: Peripheral arterial disease (PAD) is a common condition, in which atherosclerotic narrowing in the arteries restricts blood supply to the leg muscles. In order to support future model-based economic evaluations comparing methods of diagnosis in this area, a systematic review of economic modelling studies was conducted.

Methods: A systematic literature review was performed in June 2017 to identify model-based economic evaluations of diagnostic tests to detect PAD, with six individual databases searched. The review was conducted in accordance with the methods outlined in the Centre for Reviews and Dissemination's guidance for undertaking reviews in healthcare, and appropriate inclusion criteria were applied. Relevant data were extracted, and studies were quality assessed.

Results: Seven studies were included in the final review, all of which were published between 1995 and 2014. There was wide variation in the types of diagnostic test compared. The majority of the studies (six of seven) referenced the sources used to develop their model, and all studies stated and justified the structural assumptions. Reporting of the data within the included studies could have been improved. Only one identified study focused on the cost-effectiveness of a test typically used in primary care.

Conclusions: This review brings together all applied modelling methods for tests used in the diagnosis of PAD, which could be used to support future model-based economic evaluations in this field. The limited modelling work available on tests typically used for the detection of PAD in primary care, in particular, highlights the importance of future work in this area.

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Conflict of interest statement

Relationships with entities that have a financial interest in the subject matter of the article have been clearly stated in the Conflict of Interest Disclosure Statements provided by Andrew Sims and John Allen. These relationships relate to their employment by the Newcastle upon Tyne Hospitals (NUTH) NHS Foundation Trust, which received grant income from the National Institute for Health Research to develop the diagnostic device outlined previously. Authors Eoin Moloney, Joanne O’Connor, Dawn Craig, Shannon Robalino, Alexandros Chrysos, Mehdi Javanbakht, Gerard Stansby and Scott Wilkes have no conflicts of interest to report.

Figures

Fig. 1
Fig. 1
Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) flowchart of selection process for included studies
See this image and copyright information in PMC

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