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Comment
. 2018 Oct 15;67(9):1474-1476.
doi: 10.1093/cid/ciy350.

Role of Egg-adaptation Mutations in Low Influenza A(H3N2) Vaccine Effectiveness During the 2012-2013 Season

Danuta M Skowronski  1   2 , Gaston De Serres  3   4
Affiliations
Comment

Role of Egg-adaptation Mutations in Low Influenza A(H3N2) Vaccine Effectiveness During the 2012-2013 Season

Danuta M Skowronski et al. Clin Infect Dis. .
No abstract available

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Comment in

  • Response to Skowronski and De Serres.
    Cobey S, Grad YH. Cobey S, et al. Clin Infect Dis. 2018 Oct 15;67(9):1476. doi: 10.1093/cid/ciy352. Clin Infect Dis. 2018. PMID: 29688302 Free PMC article. No abstract available.

Comment on

References

    1. Skowronski DM, Janjua NZ, De Serres G, et al. . Low 2012-13 influenza vaccine effectiveness associated with mutation in the egg-adapted H3N2 vaccine strain not antigenic drift in circulating viruses. PLoS One 2014; 9:e92153. - PMC - PubMed
    1. Koel BF, Burke DF, Bestebroer TM, et al. . Substitutions near the receptor binding site determine major antigenic change during influenza virus evolution. Science 2013; 342:976–9. - PubMed
    1. Cobey S, Gouma S, Parkhouse K, et al. . Poor immunogenicity, not vaccine strain egg adaptation, may explain the low H3N2 influenza vaccine effectiveness in 2012–13. Clin Infect Dis 2018; 67:327–333. - PMC - PubMed
    1. Zost SJ, Parkhouse K, Gumina ME, et al. . Contemporary H3N2 influenza viruses have a glycosylation site that alters binding of antibodies elicited by egg-adapted vaccine strains. Proc Natl Acad Sci U S A 2017; 114:12578–83. - PMC - PubMed
    1. Skowronski DM, Chambers C, Sabaiduc S, et al. . Interim estimates of 2016/17 vaccine effectiveness against influenza A(H3N2), Canada, January 2017. Euro Surveill 2017; 22:pii=30460 doi:10.2807/1560-7917.ES.2017.22.6.30460 - PMC - PubMed

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