Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2018 Oct 1;11(7):175-180.
doi: 10.1213/XAA.0000000000000775.

When All Else Fails: Novel Use of Angiotensin II for Vasodilatory Shock: A Case Report

Affiliations
Case Reports

When All Else Fails: Novel Use of Angiotensin II for Vasodilatory Shock: A Case Report

Jonathan H Chow et al. A A Pract. .

Abstract

Angiotensin (AT) II is an endogenous hormone that acts on venous and arterial smooth muscle to cause vasoconstriction. Recent trials have sparked great interest in its ability to be used as a vasopressor for catecholamine-refractory hypotension. Herein, we describe the successful use of AT II in a patient with a colonic perforation with septic shock refractory to conventional treatment. After AT II initiation, there was an immediate reduction in catecholamine requirement, and the patient survived.

PubMed Disclaimer

References

    1. Chawla LS, Busse L, Brasha-Mitchell E, et al. Intravenous Angiotensin II for the Treatment of High-Output Shock (ATHOS trial): a pilot study. Crit Care. 2014;18:534.
    1. Khanna A, English SW, Wang XS, et al.; ATHOS-3 Investigators. Angiotensin II for the treatment of vasodilatory shock. N Engl J Med. 2017;377:419430.
    1. Basso N, Terragno NA. History about the discovery of the renin-angiotensin system. Hypertension. 2001;38:12461249.
    1. Struthers AD, MacDonald TM. Review of aldosterone- and angiotensin II-induced target organ damage and prevention. Cardiovasc Res. 2004;61:663670.
    1. Busse LW, McCurdy MT, Ali O, Hall A, Chen H, Ostermann M. The effect of angiotensin II on blood pressure in patients with circulatory shock: a structured review of the literature. Crit Care. 2017;21:324.

Publication types

MeSH terms

LinkOut - more resources