Autophagosome Formation: Cutting the Gordian Knot at the ER

Bhawana Bissa¹, Vojo Deretic²

Affiliations

¹ Autophagy Inflammation and Metabolism (AIM) Center of Biomedical Research Excellence, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE, Albuquerque, NM 87131, USA; Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE, Albuquerque, NM 87131, USA.
² Autophagy Inflammation and Metabolism (AIM) Center of Biomedical Research Excellence, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE, Albuquerque, NM 87131, USA; Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE, Albuquerque, NM 87131, USA. Electronic address: VDeretic@salud.unm.edu.

PMID: 29689207
DOI: 10.1016/j.cub.2018.03.015

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Autophagosome Formation: Cutting the Gordian Knot at the ER

Bhawana Bissa et al. Curr Biol. 2018.

Free article

. 2018 Apr 23;28(8):R347-R349.

doi: 10.1016/j.cub.2018.03.015.

Authors

Bhawana Bissa¹, Vojo Deretic²

Affiliations

¹ Autophagy Inflammation and Metabolism (AIM) Center of Biomedical Research Excellence, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE, Albuquerque, NM 87131, USA; Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE, Albuquerque, NM 87131, USA.
² Autophagy Inflammation and Metabolism (AIM) Center of Biomedical Research Excellence, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE, Albuquerque, NM 87131, USA; Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, 915 Camino de Salud, NE, Albuquerque, NM 87131, USA. Electronic address: VDeretic@salud.unm.edu.

PMID: 29689207
DOI: 10.1016/j.cub.2018.03.015

Abstract

Autophagosome biogenesis and the origins of its isolation membrane have been a long-standing unresolved question, with the endoplasmic reticulum and its membrane contact sites with other organelles remaining the prime suspect. This concept has now been reinforced by recent advances uncovering roles of several ER membrane proteins in autophagosome formation.

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The ER Contact Proteins VAPA/B Interact with Multiple Autophagy Proteins to Modulate Autophagosome Biogenesis.
Zhao YG, Liu N, Miao G, Chen Y, Zhao H, Zhang H. Zhao YG, et al. Curr Biol. 2018 Apr 23;28(8):1234-1245.e4. doi: 10.1016/j.cub.2018.03.002. Epub 2018 Apr 5. Curr Biol. 2018. PMID: 29628370

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Autophagosome Formation: Cutting the Gordian Knot at the ER

Affiliations

Autophagosome Formation: Cutting the Gordian Knot at the ER

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Abstract

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