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Review
. 2018 Apr 23;28(8):R411-R416.
doi: 10.1016/j.cub.2017.12.013.

The dynamin superfamily

Rajesh Ramachandran  1 , Sandra L Schmid  2
Affiliations
Free article
Review

The dynamin superfamily

Rajesh Ramachandran et al. Curr Biol. .
Free article

Abstract

The dynamin superfamily comprises a growing assortment of multi-domain GTPases, found from bacteria to man, that are distinguished from typical GTPases of the Ras, Rab and G-protein families by their modular structure (Figure 1), relatively large size (>70 kDa), and low affinity for guanine nucleotides. In addition, they display a conserved propensity to self-assemble into polymeric arrays, the dynamics of which are regulated by an autonomous, assembly-stimulated GTPase activity.

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