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Comment
. 2018 May 8;115(19):4810-4812.
doi: 10.1073/pnas.1805129115. Epub 2018 Apr 24.

Transient pausing by RNA polymerase II

David H Price  1
Affiliations
Comment

Transient pausing by RNA polymerase II

David H Price. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The author declares no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Residence times of Pol II during the three states of Pol II interaction with DNA. The diagram depicts the average time Pol II spends associated with DNA during initiation, pausing, and productive elongation. The fate of Pol II in each of the phases of transcription is indicated as the percentage that dissociates from the DNA versus the percentage that enters the next phase. Values were calculated by Steurer et al. (2).
See this image and copyright information in PMC

Comment on

References

    1. Guo J, Price DH. RNA polymerase II transcription elongation control. Chem Rev. 2013;113:8583–8603. - PMC - PubMed
    1. Steurer B, et al. Live-cell analysis of endogenous GFP-RPB1 uncovers rapid turnover of initiating and promoter-paused RNA Polymerase II. Proc Natl Acad Sci USA. 2018;115:E4368–E4376. - PMC - PubMed
    1. Marshall NF, Price DH. Control of formation of two distinct classes of RNA polymerase II elongation complexes. Mol Cell Biol. 1992;12:2078–2090. - PMC - PubMed
    1. Darzacq X, et al. In vivo dynamics of RNA polymerase II transcription. Nat Struct Mol Biol. 2007;14:796–806. - PMC - PubMed
    1. Nilson KA, et al. Oxidative stress rapidly stabilizes promoter-proximal paused Pol II across the human genome. Nucleic Acids Res. 2017;45:11088–11105. - PMC - PubMed

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