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Review
. 2018;14(2):76-85.
doi: 10.2174/1573402114666180423110658.

Quantitative Vascular Evaluation: From Laboratory Experiments to Point-of-Care Patient (Experimental Approach)

Ricardo L Armentano  1   2   3 , Leandro J Cymberknop  1   2
Affiliations
Review

Quantitative Vascular Evaluation: From Laboratory Experiments to Point-of-Care Patient (Experimental Approach)

Ricardo L Armentano et al. Curr Hypertens Rev. 2018.

Abstract

This paper illustrates the evolution of our knowledge of arterial mechanics from our initial research works up to the present time. Several techniques focusing on this topic in terms of our experience are discussed. An interdisciplinary team composed by different institutions from Argentina, Uruguay, France and Spain was created to conduct research, to train human resources and to fulfill the inevitable social role of gaining access to technological innovation to improve public health.

Keywords: Arterial wall; collagen; elastin; endothelium; smooth muscle; vascular mechanics..

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Figures

Fig. (1)
Fig. (1)
Left panel: Types of solid state microtransducers (Konigsberg Inc. & Millar Inc.) Right panel: Microcrystal used to measure vascular diameters. In all cases, the piezoelectric ceramic is welded to a bipolar cable and coated with a polyurethane resin lens [7].
Fig. (2)
Fig. (2)
Modeling of the arterial wall based on elastic (E) and viscous passive (ηP) components according to the stress applied (σ). SEC is Serial Elastic (E) Component. PEC is Parallel Elastic (E) Component (a) Maxwell Model (b) Voight Model (c) St. Venant Model.
Fig. (3)
Fig. (3)
Modeling of the arterial wall and incorporation of the recruitment function of the collagen fibers. The latter activate (hook) according to the level of stress exerted on the wall, showing a nonlinear response.
Fig. (4)
Fig. (4)
Individual contribution of the elastic, viscous and inertial properties of the mechanical behavior of the arterial wall, evaluated in the stress-strain relationship.
Fig. (5)
Fig. (5)
Holistic view of vascular dynamics: Continent (arterial wall), content (blood) and their interaction.
See this image and copyright information in PMC

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