Fine-Tuning Mitochondrial Dysfunction and Reductive Carboxylation

Christopher J Halbrook¹, Zeribe C Nwosu¹, Costas A Lyssiotis²

Affiliations

¹ Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
² Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA; Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI, USA; Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI, USA; http://lyssiotislab.com. Electronic address: clyssiot@med.umich.edu.

PMID: 29692332
DOI: 10.1016/j.tem.2018.04.002

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Fine-Tuning Mitochondrial Dysfunction and Reductive Carboxylation

Christopher J Halbrook et al. Trends Endocrinol Metab. 2018 Sep.

. 2018 Sep;29(9):599-602.

doi: 10.1016/j.tem.2018.04.002. Epub 2018 Apr 23.

Authors

Christopher J Halbrook¹, Zeribe C Nwosu¹, Costas A Lyssiotis²

Affiliations

¹ Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
² Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA; Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI, USA; Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI, USA; http://lyssiotislab.com. Electronic address: clyssiot@med.umich.edu.

PMID: 29692332
DOI: 10.1016/j.tem.2018.04.002

Abstract

Metabolic processes within cells are dynamically interconnected. If mitochondria become defective, cells must rewire their metabolism to survive. Here we highlight recent work by Gaude et al. that used a tunable model of mitochondrial dysfunction combined with metabolic tracing and in silico analyses to define these compensatory pathways.

Keywords: GAPDH; MDH1; NAD/NADH; glycolysis; redox.

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NADH Shuttling Couples Cytosolic Reductive Carboxylation of Glutamine with Glycolysis in Cells with Mitochondrial Dysfunction.
Gaude E, Schmidt C, Gammage PA, Dugourd A, Blacker T, Chew SP, Saez-Rodriguez J, O'Neill JS, Szabadkai G, Minczuk M, Frezza C. Gaude E, et al. Mol Cell. 2018 Feb 15;69(4):581-593.e7. doi: 10.1016/j.molcel.2018.01.034. Mol Cell. 2018. PMID: 29452638 Free PMC article.

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Fine-Tuning Mitochondrial Dysfunction and Reductive Carboxylation

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Fine-Tuning Mitochondrial Dysfunction and Reductive Carboxylation

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