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Review
. 2018 Apr 17:13:20.
doi: 10.1186/s13020-018-0177-x. eCollection 2018.

Techniques for extraction and isolation of natural products: a comprehensive review

Qing-Wen Zhang  1 , Li-Gen Lin  1 , Wen-Cai Ye  2
Affiliations
Review

Techniques for extraction and isolation of natural products: a comprehensive review

Qing-Wen Zhang et al. Chin Med. .

Abstract

Natural medicines were the only option for the prevention and treatment of human diseases for thousands of years. Natural products are important sources for drug development. The amounts of bioactive natural products in natural medicines are always fairly low. Today, it is very crucial to develop effective and selective methods for the extraction and isolation of those bioactive natural products. This paper intends to provide a comprehensive view of a variety of methods used in the extraction and isolation of natural products. This paper also presents the advantage, disadvantage and practical examples of conventional and modern techniques involved in natural products research.

Keywords: Chromatography; Extraction; Isolation; Natural medicine; Natural products; Phytochemical investigation.

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Figures

Fig. 1
Fig. 1
Structures of compounds 1–3
Fig. 2
Fig. 2
Structures of compounds 4–6
Fig. 3
Fig. 3
Possible mechanisms of the chemical conversion of ginsenosides (7–31) in decoction
Fig. 4
Fig. 4
Structures of compounds 32–48 and 78–79
Fig. 5
Fig. 5
Structures of compounds 50–51
Fig. 6
Fig. 6
Structure of compounds 52
Fig. 7
Fig. 7
Structure of compounds 53
Fig. 8
Fig. 8
Structures of compounds 54–59
Fig. 9
Fig. 9
Structures of compounds 60–65
Fig. 10
Fig. 10
Structures of compounds 66–67
Fig. 11
Fig. 11
Structures of compounds 68–88
Fig. 12
Fig. 12
Structures of compounds 89–111
Fig. 13
Fig. 13
Structures of compounds 112–114
Fig. 14
Fig. 14
Structures of compounds 115–120
Fig. 15
Fig. 15
Structures of compounds 121–124
Fig. 16
Fig. 16
Structure of compounds 125
Fig. 17
Fig. 17
Structures of compounds 126–130
Fig. 18
Fig. 18
Structures of compounds 131–142
Fig. 19
Fig. 19
Structures of compounds 143–149
Fig. 20
Fig. 20
Structures of compounds 150–153
Fig. 21
Fig. 21
Structures of compounds 154–167
See this image and copyright information in PMC

References

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