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. 2018 Jun;17(6):8047-8052.
doi: 10.3892/mmr.2018.8917. Epub 2018 Apr 23.

Hair growth is promoted by BeauTop via expression of EGF and FGF‑7

Chien-Ying Lee  1 , Chi-Yu Yang  2 , Ching-Che Lin  3 , Min-Chien Yu  4 , Shuenn-Jyi Sheu  3 , Yu-Hsiang Kuan  1
Affiliations

Hair growth is promoted by BeauTop via expression of EGF and FGF‑7

Chien-Ying Lee et al. Mol Med Rep. 2018 Jun.

Abstract

Minoxidil and finasteride have been approved to treat hair loss by the Food and Drug Administration. However, the further elucidation of treatments for hair loss, including those using Chinese herbal medicine, remains important clinically. BeauTop (BT) is a health food supplement which contains Ginseng radix, Astragali radix, Radix Angelicae sinensis, Ligustri fructus, Rehmannia glutinosa and Eclipta prostrata (Linn). Susbsequent to oral administration of BT at 0.6 g/kg/day to wax/rosin‑induced alopecia in C57BL/6 mice, BT significantly induced hair growth at day 8 compared with control treatment (P<0.05). The expression levels of epidermal growth factor (EGF), and fibroblast growth factor (FGF)‑7 were increased compared with control animals on day 8. In contrast, levels of FGF‑5 of the BT group were reduced compared with the control on day 12. There were no effects on the expression of insulin‑like growth factor 1. The results demonstrated that the mechanism of BT improving alopecia is potentially associated with modulation of EGF and FGF‑7 levels. Taken together, it is suggested that BT may have a potential effect of the promotion of hair growth.

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Figures

Figure 1.
Figure 1.
Hair follicle counting results. BT, BeauTop.
Figure 2.
Figure 2.
(A) Immunohistochemistical stains of epidermal growth factor. (B) The level of EGF on days 8 and 12. (C) Differences in the endpoints between days 12 and 8. BT, BeauTop.
Figure 3.
Figure 3.
(A) Immunohistochemistical stains of IGF-1. (B) The level of IGF-1 on days 8 and 12. (C) Differences in endpoints between days 12 and 8. IGF-1, insulin-like growth factor 1; BT, BeauTop.
Figure 4.
Figure 4.
(A) Immunohistochemistical stains of FGF-5. (B) The level of FGF-5 on days 8 and 12. (C) Difference in endpoints between days 12 and 8. FGF, fibroblast growth factor; BT, BeauTop.
Figure 5.
Figure 5.
(A) Immunohistochemistical stains of FGF-7. (B) The levels of FGF-7 on days 8 and 12. (C) Differences in endpoints between days 12 and 8. FGF, fibroblast growth factor; BT, BeauTop.
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