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. 2019 Jan;10(1):131-138.
doi: 10.1111/jdi.12856. Epub 2018 May 24.

Contribution and interaction of the low-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and triglyceride to diabetes in hypertensive patients: A cross-sectional study

Mengyang Hong  1   2 , Yan Ling  1 , Zhiqiang Lu  1 , Ying Liu  1 , Ping Gu  2 , Jiaqing Shao  2 , Xin Gao  1 , Xiaomu Li  1
Affiliations

Contribution and interaction of the low-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and triglyceride to diabetes in hypertensive patients: A cross-sectional study

Mengyang Hong et al. J Diabetes Investig. 2019 Jan.

Abstract

Aims/introduction: Hypertension is one of the most significant risk factors for diabetes. The present study aimed to investigate the associations of lipid profiles, including the ratio of low-density lipoprotein cholesterol (LDL-C)-to-high-density lipoprotein cholesterol (HDL-C) and triglyceride (TG) levels, as well as their interactions, with type 2 diabetes in hypertensive patients.

Materials and methods: Hypertensive patients without a history of diabetes and hypolipidemic agents were enrolled continuously at the Hypertension Clinic, Zhongshan Hospital, Fudan University (Shanghai, China) from 2014 to 2016. General clinical data, including body mass index, blood pressure, fasting glucose and 2-h post-load glucose levels, and lipid profiles, were collected. The LDL-C/HDL-C ratio, TG/HDL-C ratio and TC/HDL-C ratio were separately calculated. Statistical analyses were carried out by using SPSS software (version 13.0).

Results: In total, 935 hypertensive patients were included, of which 114 patients (12.2%) were diagnosed with diabetes. After multivariate adjustments, the LDL-C/HDL-C ratio and TG levels had the most significant and independent associations with diabetes. In the multivariate logistic regression, the LDL-C/HDL-C ratio and TG were independently associated with diabetes. After the interaction variable was included, the LDL-C/HDL-C ratio remained independently associated with diabetes, but TG was replaced by TG*LDL-C/HDL-C.

Conclusions: In conclusion, elevated LDL-C/HDL-C ratios and TG levels were associated with diabetes in patients with hypertension, with an interactive effect of the LDL-C/HDL-C ratio and TG on diabetes in the hypertensive population.

Keywords: Diabetes; Hypertension; Lipid abnormality.

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Figures

Figure 1
Figure 1
Correlation of triglyceride (TG) levels with homeostatic model assessment of insulin resistance (HOMA‐IR) and of the low‐density lipoprotein cholesterol (LDL‐C)/high‐density lipoprotein cholesterol (HDL‐C) ratio with homeostatic model assessment of β‐cell function (HOMA‐β). (a) TG levels were significantly correlated with HOMA‐IR, and (b) the LDL‐C/HDL‐C ratio was borderline correlated with HOMA‐β. HOMA‐IR and HOMA‐β were log‐transformed before statistical analysis; the values in the figure were back‐transformed.
Figure 2
Figure 2
Combination effect of triglyceride (TG) levels and the low‐density lipoprotein cholesterol (LDL‐C)/high‐density lipoprotein cholesterol (HDL‐C) ratio on diabetes. Combinations of TG levels and the LDL‐C/HDL‐C ratio tertiles were used to reclassify the participants into nine subgroups. The odds ratios for diabetes were obtained with participants with TG <2.5 mmol/L and LDL‐C/HDL‐C < 1.9 defined as the reference group.
See this image and copyright information in PMC

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