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Comment
. 2018 Apr 26;378(17):1643-1645.
doi: 10.1056/NEJMcibr1800808.

Prostate Cancer Metastasis - Fueled by Fat?

Cory Abate-Shen  1
Affiliations
Comment

Prostate Cancer Metastasis - Fueled by Fat?

Cory Abate-Shen. N Engl J Med. .
No abstract available

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Figures

Figure 1.
Figure 1.. Fat and Metastatic Prostate Cancer.
A recent study in mouse models by Chen et al. showed that deletion of two tumor-suppressor genes commonly lost in prostate cancer resulted in the activation of the mitogen-activated protein kinase (MAPK) pathway and increased production of lipids in prostate cancer cells (Panel A). The authors observed a similar effect when the mice were fed a high-fat diet, and they found that the effect was suppressed with the administration of fatostatin, a molecule that blocks adipogenesis (Panel B). Upward arrows indicate increased, and downward arrows decreased.
See this image and copyright information in PMC

Comment on

  • Prenatal Correction of X-Linked Hypohidrotic Ectodermal Dysplasia.
    Schneider H, Faschingbauer F, Schuepbach-Mallepell S, Körber I, Wohlfart S, Dick A, Wahlbuhl M, Kowalczyk-Quintas C, Vigolo M, Kirby N, Tannert C, Rompel O, Rascher W, Beckmann MW, Schneider P. Schneider H, et al. N Engl J Med. 2018 Apr 26;378(17):1604-1610. doi: 10.1056/NEJMoa1714322. N Engl J Med. 2018. PMID: 29694819

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