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. 2018 Apr 25;10(1):43.
doi: 10.1186/s13195-018-0371-1.

Cross-sectional associations of plasma vitamin D with cerebral β-amyloid in older adults at risk of dementia

Fati Nourhashemi  1   2   3   4 , Claudie Hooper  5 , Christelle Cantet  1   2   3   4 , Catherine Féart  6 , Isabelle Gennero  7   8 , Pierre Payoux  9   10 , Anne Sophie Salabert  9   10 , Sophie Guyonnet  1   2   3   4 , Philipe De Souto Barreto  1   2   3   4 , Bruno Vellas  1   2   3   4 ; Multidomain Alzheimer Preventive Trial/Data sharing Alzheimer (DSA) study group
Collaborators, Affiliations

Cross-sectional associations of plasma vitamin D with cerebral β-amyloid in older adults at risk of dementia

Fati Nourhashemi et al. Alzheimers Res Ther. .

Abstract

Background: Vitamin D deficiency is associated with an increased risk of Alzheimer's disease and increased beta-amyloid (Aβ) in animals. Hence we sought to investigate the relationship between plasma 25-hydroxyvitamin D (25(OH)D) and cerebral Aβ in older adults with subjective memory complaints.

Methods: This is a secondary analysis of the Multidomain Alzheimer Preventive Trial. Participants were 178 dementia-free individuals aged 70 years or older with data on plasma 25(OH)D and cerebral Aβ load assessed by [18F]-florbetapir positron emission tomography. Plasma 25(OH)D was measured at study baseline using a commercially available electro-chemiluminescence competitive binding assay. Standard uptake value ratios (SUVRs) were generated using the cerebellum as a reference. Brain regions assessed included the cortex, anterior cingulate, anterior putamen, caudate, hippocampus, medial orbitofrontal cortex, occipital cortex, parietal cortex, pons, posterior cingulate, posterior putamen, precuneus, semioval centre and temporal cortex. Associations were explored using fully adjusted multiple linear regression models.

Results: Participants had a mean (SD) age of 76.2 years (4.4) and 59.6% were female. The mean (SD) plasma 25(OH)D level was 22.4 ng/ml (10.8) and the mean (SD) cortical SUVR was 1.2 (0.2). We did not find any cross-sectional associations (p > 0.05) between baseline 25(OH)D levels and Aβ in any of the brain regions studied.

Conclusions: These preliminary results suggest that circulating 25(OH)D is not associated with cerebral Aβ in older adults. Further longitudinal studies with the measurement of mid-life vitamin D status are required to explore the relationship between vitamin D and Aβ accrual over time, thereby circumventing the shortfalls of a cross-sectional study.

Keywords: Alzheimer’s disease; Beta-amyloid; Positron emission tomography; Vitamin D.

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Conflict of interest statement

Ethics approval and consent to participate

Both the MAPT and PET sub-study described in this manuscript were approved by the ethical committee in Toulouse (CPP SOOM II) and have therefore been performed in accordance with the 1964 Declaration of Helsinki and its later amendments. Written consent was obtained from all participants.

Competing interests

The authors declare that they have no competing interests.

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