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. 2018 May-Jun;32(3):561-565.
doi: 10.21873/invivo.11276.

Circulating microRNAs as Novel Biomarkers for Atherosclerosis

Seda Gulec Yilmaz  1 , Selim Isbir  2 , Atike Tekeli Kunt  3 , Turgay Isbir  4
Affiliations

Circulating microRNAs as Novel Biomarkers for Atherosclerosis

Seda Gulec Yilmaz et al. In Vivo. 2018 May-Jun.

Abstract

Background/aim: In this study, we determined the expression of selected circulating microRNAs (miRNA) and their potential roles as biomarkers in patients with atherosclerosis and a control group.

Materials and methods: In order to obtain insight into miRNA expression levels in atherosclerosis, we analyzed miRNA expression levels by real-time polymerase chain reaction (RT-PCR) in case (n=89) and healthy control (n=93) groups. Receiver operating characteristic curve analysis was performed to assess the diagnostic capability of miRNAs.

Results: miRNA221 and miRNA221 expression levels were significantly lower in patients than controls (p=0.011 and p=0.004, respectively). Receiver operator curve analysis demonstrated that expression levels of miRNA221 [area under curve (AUC)=0.623, p=0.0086) and miRNA222 (AUC=0.654, p=0.0006) were significantly different between groups. There were positive correlations between miRNA122a and triglyceride (p=0.046) and very-low-density lipoprotein (p=0.029) levels.

Conclusion: miRNA221 and miRNA222 could be convenient biomarkers for diagnosis of atherosclerosis.

Keywords: Atherosclerosis; biomarker; miRNA122a; miRNA221; miRNA222.

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Figures

Figure 1
Figure 1. The expression of circulating miRNAs in patients with atherosclerosis. B, C: Receiver operator characteristic curves for linear regression of expression levels of circulating miRNA221 (B) and miRNA222 (C).
See this image and copyright information in PMC

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