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. 2018 May-Jun;32(3):597-602.
doi: 10.21873/invivo.11281.

A Pathological Study Using 2014 WHO Criteria Reveals Poor Prognosis of Grade 3 Ovarian Endometrioid Carcinomas

Hiroaki Soyama  1 , Morikazu Miyamoto  2 , Masashi Takano  3 , Hideki Iwahashi  1 , Kento Kato  1 , Takahiro Sakamoto  1 , Mika Kuwahara  1 , Hiroki Ishibashi  1 , Hiroko Matuura  1 , Tomoyuki Yoshikawa  3 , Tadashi Aoyama  1 , Hitoshi Tsuda  4 , Kenichi Furuya  1
Affiliations

A Pathological Study Using 2014 WHO Criteria Reveals Poor Prognosis of Grade 3 Ovarian Endometrioid Carcinomas

Hiroaki Soyama et al. In Vivo. 2018 May-Jun.

Abstract

Background/aim: The purpose of this study was to compare the clinical behavior of several grades of endometrioid carcinoma (EC) compared to high-grade serous carcinoma (HGSC), based on World Health Organization 2014 criteria.

Materials and methods: Clinicopathological features were compared between all grades of EC and HGSC, and between HGSC and either grade 1/2 or grade 3 EC.

Results: Sixty-five patients with EC and 214 with HGSC were identified. Among patients with EC, 56 displayed 1/2 EC and nine had grade 3 EC. The progression-free (PFS) and overall (OS) survival of patients with grade 1/2 EC were better than of those of patients with HGSC; however, PFS and OS did not statistically differ between patients with grade 3 EC and those with HGSC. Grade 1/2 EC, but not grade 3, was a better prognostic factor compared with HGSC.

Conclusion: A grading system for EC would be beneficial for the accurate prognosis of ovarian cancer.

Keywords: Ovarian endometrioid carcinoma; World Health Organization 2014 criteria; ovarian high-grade serous carcinoma; prognosis.

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Figures

Figure 1
Figure 1. Kaplan–Meier analyses of progression-free (A) and overall (B) survival in patients with all grades of endometrioid carcinoma (EC; n=65) and high-grade serous carcinoma (HGSC; n=214).
Figure 2
Figure 2. Kaplan–Meier analyses of progression-free (A) and overall (B) survival of patients with grade 1 and 2 endometrioid carcinoma (EC), grade 3 EC (n=9), and high-grade serous carcinoma (HGSC).
See this image and copyright information in PMC

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