Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1988 Jul 29;241(4865):585-9.
doi: 10.1126/science.2969618.

cDNA expression cloning of the IL-1 receptor, a member of the immunoglobulin superfamily

J E Sims  1 , C J March, D Cosman, M B Widmer, H R MacDonald, C J McMahan, C E Grubin, J M Wignall, J L Jackson, S M Call, et al.
Affiliations

cDNA expression cloning of the IL-1 receptor, a member of the immunoglobulin superfamily

J E Sims et al. Science. .

Abstract

Interleukin-1 alpha and -1 beta (IL-1 alpha and IL-1 beta) are cytokines that participate in the regulation of immune responses, inflammatory reactions, and hematopoiesis. A direct expression strategy was used to clone the receptor for IL-1 from mouse T cells. The product of the cloned complementary DNA binds both IL-1 alpha and IL-1 beta in a manner indistinguishable from that of the native T cell IL-1 receptor. The extracellular, IL-1 binding portion of the receptor is 319 amino acids in length and is composed of three immunoglobulin-like domains. The cytoplasmic portion of the receptor is 217 amino acids long.

PubMed Disclaimer

Publication types

Associated data

LinkOut - more resources