Expert statement for the management of hypovolemia in sepsis

doi:10.1007/s00134-018-5177-x

Review

. 2018 Jun;44(6):791-798.

doi: 10.1007/s00134-018-5177-x. Epub 2018 Apr 25.

Expert statement for the management of hypovolemia in sepsis

Anders Perner¹, Maurizio Cecconi², Maria Cronhjort³, Michael Darmon^{4

5

6}, Stephan M Jakob⁷, Ville Pettilä⁸, Iwan C C van der Horst⁹

Affiliations

¹ Department of Intensive Care, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. anders.perner@regionh.dk.
² Department Anaesthesia and Intensive Care Units, IRCCS Istituto Clinico Humanitas, Humanitas University, Milan, Italy.
³ Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
⁴ Medical ICU, Saint-Louis University Hospital, AP-HP, Paris, France.
⁵ ECSTRA Team, Biostatistics and Clinical Epidemiology, UMR 1153 (Center of Epidemiology and Biostatistic Sorbonne Paris Cité, CRESS), INSERM, Paris, France.
⁶ Paris-7 Medical School, Université Paris-Diderot, Sorbonne-Paris-Cité, Paris, France.
⁷ Department of Intensive Care Medicine, University Hospital Bern (Inselspital), University of Bern, Bern, Switzerland.
⁸ Department of Anesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
⁹ Department of Critical Care, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

PMID: 29696295
DOI: 10.1007/s00134-018-5177-x

Free article

Review

Expert statement for the management of hypovolemia in sepsis

Anders Perner et al. Intensive Care Med. 2018 Jun.

Free article

. 2018 Jun;44(6):791-798.

doi: 10.1007/s00134-018-5177-x. Epub 2018 Apr 25.

Authors

Anders Perner¹, Maurizio Cecconi², Maria Cronhjort³, Michael Darmon^{4

5

6}, Stephan M Jakob⁷, Ville Pettilä⁸, Iwan C C van der Horst⁹

Affiliations

¹ Department of Intensive Care, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. anders.perner@regionh.dk.
² Department Anaesthesia and Intensive Care Units, IRCCS Istituto Clinico Humanitas, Humanitas University, Milan, Italy.
³ Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
⁴ Medical ICU, Saint-Louis University Hospital, AP-HP, Paris, France.
⁵ ECSTRA Team, Biostatistics and Clinical Epidemiology, UMR 1153 (Center of Epidemiology and Biostatistic Sorbonne Paris Cité, CRESS), INSERM, Paris, France.
⁶ Paris-7 Medical School, Université Paris-Diderot, Sorbonne-Paris-Cité, Paris, France.
⁷ Department of Intensive Care Medicine, University Hospital Bern (Inselspital), University of Bern, Bern, Switzerland.
⁸ Department of Anesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
⁹ Department of Critical Care, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

PMID: 29696295
DOI: 10.1007/s00134-018-5177-x

Abstract

Hypovolemia is frequent in patients with sepsis and may contribute to worse outcome. The management of these patients is impeded by the low quality of the evidence for many of the specific components of the care. In this paper, we discuss recent advances and controversies in this field and give expert statements for the management of hypovolemia in patients with sepsis including triggers and targets for fluid therapy and volumes and types of fluid to be given. Finally, we point to unanswered questions and suggest a roadmap for future research.

Keywords: Critical care; Fluid therapy; Hemodynamics; Hypovolemia; Sepsis; Shock.

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References

1. Crit Care Resusc. 2016 Jun;18(2):78-88 - PubMed
1. BMJ Open. 2017 Sep 27;7(9):e017170 - PubMed
1. Intensive Care Med. 2015 Sep;41(9):1549-60 - PubMed
1. N Engl J Med. 2012 Nov 15;367(20):1901-11 - PubMed
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[1] Crit Care Resusc. 2016 Jun;18(2):78-88 - PubMed

[2] Crit Care Resusc. 2016 Jun;18(2):78-88 - PubMed

[3] BMJ Open. 2017 Sep 27;7(9):e017170 - PubMed

[4] BMJ Open. 2017 Sep 27;7(9):e017170 - PubMed

[5] Intensive Care Med. 2015 Sep;41(9):1549-60 - PubMed

[6] Intensive Care Med. 2015 Sep;41(9):1549-60 - PubMed

[7] N Engl J Med. 2012 Nov 15;367(20):1901-11 - PubMed

[8] N Engl J Med. 2012 Nov 15;367(20):1901-11 - PubMed

[9] Crit Care. 2005 Aug;9(4):R363-74 - PubMed

[10] Crit Care. 2005 Aug;9(4):R363-74 - PubMed

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Expert statement for the management of hypovolemia in sepsis

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Expert statement for the management of hypovolemia in sepsis

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