Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Jun;29(2):183-186.
doi: 10.1007/s00399-018-0563-1. Epub 2018 Apr 25.

Orthostatic intolerance and postural tachycardia syndrome: new insights into pathophysiology and treatment

Mohammed Ruzieh  1 , Blair P Grubb  2
Affiliations
Review

Orthostatic intolerance and postural tachycardia syndrome: new insights into pathophysiology and treatment

Mohammed Ruzieh et al. Herzschrittmacherther Elektrophysiol. 2018 Jun.

Abstract

Orthostatic intolerance is characterized by symptoms of light-headedness or syncope that is provoked upon standing or in an upright posture. It is most commonly caused by postural orthostatic tachycardia syndrome (POTS) or orthostatic hypotension (OH). Its pathophysiology is complex and commonly involves abnormal autonomic nervous system regulation, autoimmunity, a hyperadrenergic state, and hypovolemia. This article reviews the pathophysiology underlying orthostatic intolerance, as well as the current treatment available.

Keywords: Autoimmunity; Hypovolemia; Orthostatic hypotension; Pathophysiology; Postural tachycardia syndrome.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Circulation. 1999 Apr 6;99(13):1706-12 - PubMed
    1. Neurology. 1989 Jan;39(1):34-40 - PubMed
    1. J Intern Med. 2013 Apr;273(4):322-35 - PubMed
    1. Clin Sci (Lond). 1989 Sep;77(3):265-72 - PubMed
    1. Heart Rhythm. 2015 Jun;12(6):e41-63 - PubMed

LinkOut - more resources