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Comment
. 2018 Jun 1;66(12):1937-1939.
doi: 10.1093/cid/ciy188.

A Therapeutic Vaccine for Recurrent Vulvovaginal Candidiasis

Arturo Casadevall  1 , Liise-Anne Pirofski  2
Affiliations
Comment

A Therapeutic Vaccine for Recurrent Vulvovaginal Candidiasis

Arturo Casadevall et al. Clin Infect Dis. .
No abstract available

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Figures

Figure 1.
Figure 1.
Proposal for how the NDV-3A vaccine may mediate protection from the view of the damage-response (DRF) of microbial pathogenesis. The DRF posits that disease occurs in the setting of disproportionately, or inappropriately, weak or strong immune responses. According to the DRF, the vaccine may work by eliciting an antibody response that reduces the vaginal immune response to Candida. This would result in a reduction in the inflammatory response, which in would in turn move the outcome of host-microbe interaction to the left, resulting in reduced damage, fewer clinical symptoms, and fewer recurrences of vulvovaginal candidiasis.
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References

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