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. 2018 Jul 1;36(19):1902-1904.
doi: 10.1200/JCO.2017.77.0479. Epub 2018 Apr 26.

Bias, Operational Bias, and Generalizability in Phase II/III Trials

Boris Freidlin  1 , Edward L Korn  1 , Jeffrey S Abrams  1
Affiliations

Bias, Operational Bias, and Generalizability in Phase II/III Trials

Boris Freidlin et al. J Clin Oncol. .
No abstract available

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References

    1. Bretz F, Schmidli H, König F, et al. Confirmatory seamless phase II/III clinical trials with hypotheses selection at interim: General concepts. Biom J. 2006;48:623–634. - PubMed
    1. Korn EL, Freidlin B, Abrams JS, et al. Design issues in randomized phase II/IIItrials. J Clin Oncol. 2012;30:667–671. - PMC - PubMed
    1. Wang M, Dignam JJ, Zhang QE, et al. Integrated phase II/III clinical trials in oncology: A case study. Clin Trials. 2012;9:741–747. - PMC - PubMed
    1. Redman MW, Goldman BH, LeBlanc M, et al. Modeling the relationship between progression-free survival and overall survival: The phase II/III trial. Clin Cancer Res. 2013;19:2646–2656. - PMC - PubMed
    1. Goldman B, LeBlanc M, Crowley J. Interim futility analysis with intermediate endpoints. Clin Trials. 2008;5:14–22. - PubMed

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