doi: 10.1016/0014-2999(88)90765-0.
Atrial natriuretic factor inhibits norepinephrine release in an adrenergic clonal cell line (PC12)
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- PMID: 2969821
- DOI: 10.1016/0014-2999(88)90765-0
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Atrial natriuretic factor inhibits norepinephrine release in an adrenergic clonal cell line (PC12)
Eur J Pharmacol.
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Abstract
Evidence for a presynaptic neuromodulatory effect of atrial natriuretic factor (ANF) has been obtained in rat adrenal pheochromocytoma cells (PC12), a clonal line that differentiates into adrenergic neuron-like cells when treated with nerve growth factor. ANF had no effect on basal norepinephrine (NE) release. In contrast, ANF markedly and significantly inhibited carbachol-induced NE release in a concentration-dependent manner. This result is consistent with the hypothesis that ANF may be an inhibitory neuromodulator.
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