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. 1988 May 20;150(1-2):175-9.
doi: 10.1016/0014-2999(88)90765-0.

Atrial natriuretic factor inhibits norepinephrine release in an adrenergic clonal cell line (PC12)

J Drewett  1 , G Marchand, R Ziegler, G Trachte
Affiliations

Atrial natriuretic factor inhibits norepinephrine release in an adrenergic clonal cell line (PC12)

J Drewett et al. Eur J Pharmacol. .

Abstract

Evidence for a presynaptic neuromodulatory effect of atrial natriuretic factor (ANF) has been obtained in rat adrenal pheochromocytoma cells (PC12), a clonal line that differentiates into adrenergic neuron-like cells when treated with nerve growth factor. ANF had no effect on basal norepinephrine (NE) release. In contrast, ANF markedly and significantly inhibited carbachol-induced NE release in a concentration-dependent manner. This result is consistent with the hypothesis that ANF may be an inhibitory neuromodulator.

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