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. 2018 Apr 26;13(4):e0195288.
doi: 10.1371/journal.pone.0195288. eCollection 2018.

Clinical manifestations in infants and children with Mycoplasma pneumoniae infection

Mia Johanna Søndergaard  1 , Martin Barfred Friis  2 , Dennis Schrøder Hansen  2 , Inger Merete Jørgensen  1
Affiliations

Clinical manifestations in infants and children with Mycoplasma pneumoniae infection

Mia Johanna Søndergaard et al. PLoS One. .

Abstract

Background: Mycoplasma pneumoniae is a common cause of community-acquired pneumonia in older children. Pulmonary and extra-pulmonary symptoms associated with M. pneumoniae infection are reported. M. pneumoniae is mainly epidemic in Denmark with the recurrence every 4-7th year.

Aims: Retrospectively, to describe the epidemiology and clinical features, in infants and children, during the M. pneumoniae epidemic in 2010 and 2011.

Methods: All children under the age of 16 that were tested for M. pneumoniae during the period 01.02.2010-31.01.2012 were included. Medical charts, as well as radiological findings, were reviewed for all children with M. pneumoniae. A post-hoc analysis of viral co-infections was done on part of the cohort.

Results: 134 of 746 children were tested positive for M. pneumoniae by PCR or serology. Positive tests were found in 65% of children seven years and older, in 30% of 2-6-year-olds and 4% of infants (less than two years of age). Viral co-infection was found in 27% of the tested samples. The clinical presentation was a cough, asthma-like symptoms and low-grade fever. Extra-pulmonary symptoms were common and presented as nausea/vomiting by 33% of the children and skin manifestations by 25%. 84% of the children had a chest x-ray taken, and there were positive radiological findings in 94% of these.

Conclusion: M. pneumoniae also affected infants and young children and symptoms were similar to infections with respiratory viruses, but severe LRTI were also seen. During an up-coming epidemic, assessment of extra-pulmonary manifestations can be helpful when diagnosing M. pneumoniae infections.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Number of positive and negative M. pneumoniae tests by year and month.
See this image and copyright information in PMC

References

    1. Waites KB. New concepts of Mycoplasma pneumoniae infections in children. Pediatr Pulmonol. 2003;36: 267–278. doi: 10.1002/ppul.10346 - DOI - PubMed
    1. Hornsleth A. [The virology of acute respiratory tract infections. 1. A survey on the etiology in children]. Ugeskr Laeger. 1967;129: 1253–1258. - PubMed
    1. Hornsleth A. [The virology of acute respiratory tract infections. 2. Isolation of viruses in hospitalized children]. Ugeskr Laeger. 1967;129: 1259–1265. - PubMed
    1. Harris M, Clark J, Coote N, Fletcher P, Harnden A, McKean M, et al. British Thoracic Society guidelines for the management of community-acquired pneumonia in children: update 2011. Thorax. 2011;66 Suppl 2: ii1–23. doi: 10.1136/thoraxjnl-2011-200598 - DOI - PubMed
    1. Zalenzink D, Vallejo J. Mycoplasma pneumonia infection in children. 2009th ed. UpToDate.

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