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. 2018 Apr 26;14(4):e1006910.
doi: 10.1371/journal.ppat.1006910. eCollection 2018 Apr.

Nucleated red blood cells: Immune cell mediators of the antiviral response

Ivan Nombela  1 , Maria Del Mar Ortega-Villaizan  1
Affiliations

Nucleated red blood cells: Immune cell mediators of the antiviral response

Ivan Nombela et al. PLoS Pathog. .
No abstract available

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Schematic representation of teleost nucleated RBC immune responses against different infective (target: RBCs) or noninfective (target: other cell types) viral pathogens.
ifn-α, interferon-α; IL-8, interleukin-8; isg15, interferon-stimulated gene 15; mx, myxovirus resistance gene; pkr, protein kinase RNA-activated; RBC, red blood cell.
Fig 2
Fig 2. Constitutive expression of Mx antiviral protein in rainbow trout nucleated RBCs.
Immunofluorescence images of Mx protein expression in nucleated RBCs. FITC: Mx protein expression; DAPI: nuclei. Images were obtained using an INCell Analyzer 6000 Cell imaging system (GE Healthcare, Little Chalfont, United Kingdom). DAPI, 4’,6-diamidino-2-phenylindole; FITC, Fluorescein-5-isothiocyanate; Mx, myxovirus resistance gene; RBC, red blood cells.
See this image and copyright information in PMC

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References

    1. Moras M., Lefevre S.D., and Ostuni M.A., From Erythroblasts to Mature Red Blood Cells: Organelle Clearance in Mammals. Front Physiol, 2017. 8: p. 1076 doi: 10.3389/fphys.2017.01076 - DOI - PMC - PubMed
    1. Glomski C.A., Tamburlin J., and Chainani M., The phylogenetic odyssey of the erythrocyte. III. Fish, the lower vertebrate experience. Histol Histopathol, 1992. 7(3): p. 501–28. - PubMed
    1. Passantino L., et al., Fish immunology. I. Binding and engulfment of Candida albicans by erythrocytes of rainbow trout (Salmo gairdneri Richardson). Immunopharmacol Immunotoxicol, 2002. 24(4): p. 665–78. doi: 10.1081/IPH-120016050 - DOI - PubMed
    1. Passantino L., et al., Antigenically activated avian erythrocytes release cytokine-like factors: a conserved phylogenetic function discovered in fish. Immunopharmacol Immunotoxicol, 2007. 29(1): p. 141–52. doi: 10.1080/08923970701284664 - DOI - PubMed
    1. Morera D., et al., RNA-Seq reveals an integrated immune response in nucleated erythrocytes. PLoS ONE, 2011. 6(10): p. e26998 doi: 10.1371/journal.pone.0026998 - DOI - PMC - PubMed

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