Making Waves with Synthetic Oscillators

Affiliations

¹ Molecular Biology, Cell Biology & Biochemistry Program, Boston University, Boston, MA 02215, USA.
² Molecular Biology, Cell Biology & Biochemistry Program, Boston University, Boston, MA 02215, USA; Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA. Electronic address: mjdunlop@bu.edu.

Free article

Comment

Nicholas A Rossi et al. Cell Syst. 2018.

Free article

. 2018 Apr 25;6(4):406-407.

doi: 10.1016/j.cels.2018.04.001.

¹ Molecular Biology, Cell Biology & Biochemistry Program, Boston University, Boston, MA 02215, USA.
² Molecular Biology, Cell Biology & Biochemistry Program, Boston University, Boston, MA 02215, USA; Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA. Electronic address: mjdunlop@bu.edu.

Abstract

New synthetic oscillator designs provide independent tuning of amplitude and frequency and flexible switching between dynamic regimes.

Combining a Toggle Switch and a Repressilator within the AC-DC Circuit Generates Distinct Dynamical Behaviors.
Perez-Carrasco R, Barnes CP, Schaerli Y, Isalan M, Briscoe J, Page KM. Perez-Carrasco R, et al. Cell Syst. 2018 Apr 25;6(4):521-530.e3. doi: 10.1016/j.cels.2018.02.008. Epub 2018 Mar 21. Cell Syst. 2018. PMID: 29574056 Free PMC article.
Computational Re-design of Synthetic Genetic Oscillators for Independent Amplitude and Frequency Modulation.
Tomazou M, Barahona M, Polizzi KM, Stan GB. Tomazou M, et al. Cell Syst. 2018 Apr 25;6(4):508-520.e5. doi: 10.1016/j.cels.2018.03.013. Epub 2018 Apr 18. Cell Syst. 2018. PMID: 29680377