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. 2011 Sep 21;11(2):79-83.
doi: 10.1007/s12522-011-0109-2. eCollection 2012 Apr.

Comparison between the gonadotropin-releasing hormone antagonist protocol and the gonadotropin-releasing hormone agonist long protocol for controlled ovarian hyperstimulation in the first in vitro fertilization-embryo transfer cycle in an unspecified population of infertile couples

Keiko Mekaru  1 , Chiaki Yagi  1 , Kozue Asato  1 , Hitoshi Masamoto  1 , Kaoru Sakumoto  1 , Yoichi Aoki  1
Affiliations

Comparison between the gonadotropin-releasing hormone antagonist protocol and the gonadotropin-releasing hormone agonist long protocol for controlled ovarian hyperstimulation in the first in vitro fertilization-embryo transfer cycle in an unspecified population of infertile couples

Keiko Mekaru et al. Reprod Med Biol. .

Abstract

Purpose: We aimed to compare the efficacy of a gonadotropin-releasing hormone (GnRH) antagonist protocol and a GnRH agonist long protocol used in the first in vitro fertilization-embryo transfer (IVF-ET) cycle in an unspecified population of infertile couples.

Methods: Fifty and 34 patients were treated with a GnRH agonist long protocol (agonist group) and GnRH antagonist protocol (antagonist group), respectively, in the first treatment cycle. The primary and secondary outcome measures were cumulative live birth rates after fresh and cryopreserved-thawed ETs and incidence of grades II and III ovarian hyperstimulation syndrome (OHSS), respectively.

Results: No significant differences were observed in clinical pregnancy rates (38.0 vs. 32.4%) and live birth rates (22.0 vs. 23.5%), which included both fresh and cryopreserved-thawed ETs, between the 2 groups. However, the incidence of grade III OHSS was significantly lower with the GnRH antagonist protocol than the GnRH agonist long protocol.

Conclusions: Used in the first IVF-ET cycle in an unspecified population of infertile patients, the GnRH antagonist protocol showed the same clinical outcome as the GnRH agonist long protocol.

Keywords: Embryo transfer; Gonadotropin‐releasing hormone; In vitro fertilization; Ovarian hyperstimulation syndrome; Ovulation stimulation.

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References

    1. Griesinger G, Felberbaum R, Diedrich K. GnRH antagonists in ovarian stimulation: a treatment regimen of clinicians’ second choice? Data from the German National IVF Registry. Hum Reprod, 2005, 20, 2373–2375 - DOI - PubMed
    1. Hugues JN, Cedrin Durnerin IC. Revisiting gonadotropin‐releasing hormone agonist protocols and management of poor responses to gonadotropins. Hum Reprod Update, 1998, 4, 83–101 - DOI - PubMed
    1. Kowalik A, Barmat L, Damario M, Liu HC, Davis O, Rosenwaks Z. Ovarian estradiol production in vivo: inhibitory effect of leuprolide acetate. J Reprod Med, 1998, 43, 413–417 - PubMed
    1. Olivennes F, Balaish‐Allart J, Emperaire JC, Dechaud H, Alvares S, Moeau L et al. Prospective, randomized, controlled study of in vitro fertilization‐embryo transfer with a single dose of luteinizing hormone‐releasing hormone (LH‐RH) antagonist (cetrorelix) or a depot formula of LH‐RH agonist (triptorelin). Fertil Steril, 2000, 73, 314–320 - DOI - PubMed
    1. AI‐Inany HG, Abou‐Setta AM, Aboulghar M. Gonadotropin‐releasing hormone antagonists for assisted conception. Cochrane Database Syst Rev. 2006;3:CD001750. - PubMed