Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2013 Jun 1;12(4):127-132.
doi: 10.1007/s12522-013-0153-1. eCollection 2013 Oct.

Uterine receptivity and embryo-uterine interactions in embryo implantation: lessons from mice

Mahiro Egashira  1   2 , Yasushi Hirota  1   3
Affiliations
Review

Uterine receptivity and embryo-uterine interactions in embryo implantation: lessons from mice

Mahiro Egashira et al. Reprod Med Biol. .

Abstract

Implantation is a process of the first feto-maternal encounter in the uterus. A competent blastocyst and a receptive uterus are critical for successful implantation. For an acquisition of uterine receptivity, the following conditions need to be satisfied in the uterine environments: the endometrial preparation with stromal proliferation and epithelial differentiation in the pre-receptive phase and proper interactions between the uterus and blastocyst later in the phase. Focusing on these points and primarily referring to the mouse in vivo evidence, this review article has shown detailed molecular mechanisms for successful implantation.

Keywords: Cytokines; Embryo implantation; Embryo–uterine interactions; Ovarian steroid hormones; Uterine receptivity.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Figure 1
Figure 1
The process of embryo implantation
Figure 2
Figure 2
The hormonal status in early pregnancy
Figure 3
Figure 3
The secretory factors control embryo implantation
See this image and copyright information in PMC

References

    1. Dey SK, Lim H, Das SK, Reese J, Paria BC, Daikoku T et al. Molecular cues to implantation. Endocr Rev, 2004, 25, 341–373 10.1210/er.2003-0020 - DOI - PubMed
    1. Urman B, Yakin K, Balaban B. Recurrent implantation failure in assisted reproduction: how to counsel and manage. A. General considerations and treatment options that may benefit the couple. Reprod Biomed Online, 2005, 11, 371–381 10.1016/S1472-6483(10)60846-2 - DOI - PubMed
    1. Cha J, Sun X, Dey SK. Mechanisms of implantation: strategies for successful pregnancy. Nat Med, 2012, 18, 1754–1767 10.1038/nm.3012 - DOI - PMC - PubMed
    1. Stewart CL, Kaspar P, Brunet LJ, Bhatt H, Gadi I, Kontgen F et al. Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor. Nature, 1992, 359, 76–79 10.1038/359076a0 - DOI - PubMed
    1. Lim HJ, Dey SK. HB‐EGF: a unique mediator of embryo‐uterine interactions during implantation. Exp Cell Res, 2009, 315, 619–626 10.1016/j.yexcr.2008.07.025 - DOI - PMC - PubMed

LinkOut - more resources