Review
doi: 10.7861/clinmedicine.18-2-s17.
Sudden cardiac death in the young: a genetic destiny?
Affiliations
- PMID: 29700088
- PMCID: PMC6334034
- DOI: 10.7861/clinmedicine.18-2-s17
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Review
Sudden cardiac death in the young: a genetic destiny?
Clin Med (Lond).
.
No abstract available
Figures
Etiologies for sudden cardiac death in a series of 650 consecutive sudden death cases in the young and athletes in the Vento region 1980–2013.
Molecular autopsy in a boy with SCD and normal heart. A missense mutation was found in the gene encoding the ryanodine receptor II, governing the release of Ca++ from smooth sarcoplasmic reticulum for excitation-contraction coupling. The mother, during stress test, developed ventricular arrhythmias and was found to be carrier of the same gene mutation.
Multiple approaches to prevent SCD in the young, addressing the trigger, the arrhythmic mechanism, the arrest by ventricular fibrillation through defibrillator (ICD) and the etiology, the latter to find a cure of the disease.
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