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Review
. 2018 Apr 1;18(Suppl 2):s17-s23.
doi: 10.7861/clinmedicine.18-2-s17.

Sudden cardiac death in the young: a genetic destiny?

Gaetano Thiene  1
Affiliations
Review

Sudden cardiac death in the young: a genetic destiny?

Gaetano Thiene. Clin Med (Lond). .
No abstract available

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Figures

Fig 1.
Fig 1.
Etiologies for sudden cardiac death in a series of 650 consecutive sudden death cases in the young and athletes in the Vento region 1980–2013.
Fig 2.
Fig 2.
Molecular autopsy in a boy with SCD and normal heart. A missense mutation was found in the gene encoding the ryanodine receptor II, governing the release of Ca++ from smooth sarcoplasmic reticulum for excitation-contraction coupling. The mother, during stress test, developed ventricular arrhythmias and was found to be carrier of the same gene mutation.
Fig 3.
Fig 3.
Multiple approaches to prevent SCD in the young, addressing the trigger, the arrhythmic mechanism, the arrest by ventricular fibrillation through defibrillator (ICD) and the etiology, the latter to find a cure of the disease.
See this image and copyright information in PMC

References

    1. Thiene G. Sudden cardiac death and cardiovascular pathology: from anatomic theater to double helix. Am J Cardiol. 2014;114:1930–6. - PubMed
    1. Thiene G. Corrado D. Basso C. Sudden cardiac death in the young and athletes. Milano: Springer; 2016.
    1. Morgagni GB. De sedibus et causis morborum per anatomen indagatis libri quinque. Venetiis: ex typographia Remondiniana; 1761.
    1. Thiene G. Rizzo S. Basso C. Pathology of sudden death, cardiac arrhythmias and conduction system (Chapter 10) In: Buja LM, editor; Butany J, editor. Cardiovascular Pathology. 4th. Elsevier; 2015. pp. 361–433.
    1. McWilliam JA. Electrical stimulation of the heart in man. Br Med J. 1889;1:348–50. - PMC - PubMed