Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2018 Apr;97(17):e0379.
doi: 10.1097/MD.0000000000010379.

Effect of risedronate on femoral periprosthetic bone loss following total hip replacement: A systematic review and meta-analysis

Liang Ren  1 , Weidong Wang
Affiliations
Meta-Analysis

Effect of risedronate on femoral periprosthetic bone loss following total hip replacement: A systematic review and meta-analysis

Liang Ren et al. Medicine (Baltimore). 2018 Apr.

Abstract

Background: Recent study has reported that risedronate was effective in reducing periprosthesis bone loss after total hip arthroplasty (THA). The meta-analysis was performed to compare the clinical outcomes of THA with oral risedronate versus placebo.

Methods: Electronic databases: PubMed (1950-March 2018), EMBASE (1974-March 2018), the Cochrane Central Register of Controlled Trials, Web of Science (1950-March 2018) were systematically searched. Two authors independently graded the methodological quality of each eligible study using the Cochrane Collaboration tool and extracted relevant data. Statistical heterogeneity among the trials were evaluated with chi-square and I-square tests. This meta-analysis was performed using STATA 14.0.

Results: A total of 4 randomized controlled trials (RCTs) published between 2006 and 2015 were included in our study. The meta-analysis demonstrated that risedronate was associated with a significantly reduction of periprosthetic bone mineral density after THA. No increased postoperative complications were observed.

Conclusion: Oral risedronate might reduce the periprosthetic bone resorption after cementless THA. Additionally, no severe adverse effects were observed. High-quality RCTs with large sample size were still required.

PubMed Disclaimer

Conflict of interest statement

The authors declare that there is no competing interests.

Figures

Figure 1
Figure 1
Selection process.
Figure 2
Figure 2
The 7 regions of interest based on Gruen zones.
Figure 3
Figure 3
Forest plot showing the meta-analysis of the BMD in Gruen zone 1. BMD = bone mineral density.
Figure 4
Figure 4
Forest plot showing the meta-analysis of the BMD in Gruen zone 2. BMD = bone mineral density.
Figure 5
Figure 5
Forest plot showing the meta-analysis of the BMD in Gruen zone 3. BMD = bone mineral density.
Figure 6
Figure 6
Forest plot showing the meta-analysis of the BMD in Gruen zone 4. BMD = bone mineral density.
Figure 7
Figure 7
Forest plot showing the meta-analysis of the BMD in Gruen zone 5. BMD = bone mineral density.
Figure 8
Figure 8
Forest plot showing the meta-analysis of the BMD in Gruen zone 6. BMD = Bone mineral density
Figure 9
Figure 9
Forest plot showing the meta-analysis of the BMD in Gruen zone 7. BMD = Bone mineral density
Figure 10
Figure 10
Forest plot showing the meta-analysis of the post-operative complications.
Figure 11
Figure 11
Forest plot showing the meta-analysis of the hospitalization day.
See this image and copyright information in PMC

References

    1. Kawamura H, Mishima H, Sugaya H, et al. The 21- to 27-year results of the Harris-Galante cementless total hip arthroplasty. J Orthop Sci 2016;21:342–7. - PubMed
    1. Tran P, Zhang BX, Lade JA, et al. Periprosthetic bone remodeling after novel short-stem neck-sparing total hip arthroplasty. J Arthroplasty 2016;31:2530–5. - PubMed
    1. Yan SG, Li D, Yin S, et al. Periprosthetic bone remodeling of short cementless femoral stems in primary total hip arthroplasty: a systematic review and meta-analysis of randomized-controlled trials. Medicine (Baltimore) 2017;96:e8806. - PMC - PubMed
    1. Janssen L, Wijnands KAP, Janssen D, et al. Do stem design and surgical approach influence early aseptic loosening in cementless THA? Clin OrthopRelat Res 2018;doi: 10.1007/s11999.0000000000000208. - PMC - PubMed
    1. Bugbee WD, Culpepper WJ, 2nd, Engh CA, Jr, et al. Long-term clinical consequences of stress-shielding after total hip arthroplasty without cement. J Bone Joint Surg Am 1997;79:1007–12. - PubMed

MeSH terms

Substances