Imputation-based analysis of MICA alleles in the susceptibility to ankylosing spondylitis

Adrian Cortes^{1

2}, Dafna Gladman³, Soumya Raychaudhuri⁴, Jing Cui⁴, Lawrie Wheeler⁵, Matthew A Brown⁵; International Genetics of Ankylosing Spondylitis Consortium (IGAS)

Collaborators, Affiliations

Collaborators

International Genetics of Ankylosing Spondylitis Consortium (IGAS):
Bowness Paul, Wordsworth Paul, Breban Maxime, Brown Matthew, Colbert Robert, Cortes Adrian, Crusius Bart, Cui Jing, Raychaudhuri Soumya, Elewaut-Sinai Medical Dirk, Evans David, Førre Øystein, Gladman Dafna, Haroon Nigil, Elewaut-Sinai Medical Robert, Inman Dirk, Lie Benedicte, Lopez-Larrea Carlos, Maksymowych Walter, Martin Javier, Nossent Hans, Reveille John, Santos Fernando, Stebbings Simon, Tuomilehto Jaakko, Valle-Oñate Rafael, van der Horst-Bruinsma Irene, Weisman Michael

Affiliations

¹ Oxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, Division of Clinical Neurology, John Radcliffe Hospital, University of Oxford, Oxford, UK.
² Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
³ Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada.
⁴ Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
⁵ Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology (QUT) at Translational Research Institute, Brisbane, Queensland, Australia.

PMID: 29705741
PMCID: PMC6716791
DOI: 10.1136/annrheumdis-2018-213413

Imputation-based analysis of MICA alleles in the susceptibility to ankylosing spondylitis

Adrian Cortes et al. Ann Rheum Dis. 2018 Nov.

. 2018 Nov;77(11):1691-1692.

doi: 10.1136/annrheumdis-2018-213413. Epub 2018 Apr 28.

Authors

Adrian Cortes^{1

2}, Dafna Gladman³, Soumya Raychaudhuri⁴, Jing Cui⁴, Lawrie Wheeler⁵, Matthew A Brown⁵; International Genetics of Ankylosing Spondylitis Consortium (IGAS)

Collaborators

International Genetics of Ankylosing Spondylitis Consortium (IGAS):
Bowness Paul, Wordsworth Paul, Breban Maxime, Brown Matthew, Colbert Robert, Cortes Adrian, Crusius Bart, Cui Jing, Raychaudhuri Soumya, Elewaut-Sinai Medical Dirk, Evans David, Førre Øystein, Gladman Dafna, Haroon Nigil, Elewaut-Sinai Medical Robert, Inman Dirk, Lie Benedicte, Lopez-Larrea Carlos, Maksymowych Walter, Martin Javier, Nossent Hans, Reveille John, Santos Fernando, Stebbings Simon, Tuomilehto Jaakko, Valle-Oñate Rafael, van der Horst-Bruinsma Irene, Weisman Michael

Affiliations

¹ Oxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, Division of Clinical Neurology, John Radcliffe Hospital, University of Oxford, Oxford, UK.
² Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
³ Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada.
⁴ Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
⁵ Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology (QUT) at Translational Research Institute, Brisbane, Queensland, Australia.

PMID: 29705741
PMCID: PMC6716791
DOI: 10.1136/annrheumdis-2018-213413

No abstract available

Keywords: ankylosing spondylitis; gene polymorphism; inflammation.

PubMed Disclaimer

Conflict of interest statement

Competing interests: None declared.

Comment in

Imputation-based analysis of MICA alleles in the susceptibility to ankylosing spondylitis.
Zhou X, Reveille JD. Zhou X, et al. Ann Rheum Dis. 2020 Jan;79(1):e1. doi: 10.1136/annrheumdis-2018-214708. Epub 2019 Jan 18. Ann Rheum Dis. 2020. PMID: 30659049 No abstract available.
Response to: Imputation-based analysis of MICA alleles in the susceptibility to ankylosing spondylitis by Zhou et al.
Cortes A, Brown MA. Cortes A, et al. Ann Rheum Dis. 2020 Jan;79(1):e2. doi: 10.1136/annrheumdis-2018-214765. Epub 2019 Jan 18. Ann Rheum Dis. 2020. PMID: 30659051 No abstract available.

References

1. Evans DM, Spencer CC, Pointon JJ, et al. Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility. Nat Genet 2011;43:761–7. - PMC - PubMed
1. Li Z, Brown MA. Progress of genome-wide association studies of ankylosing spondylitis. Clin Transl Immunology 2017;6:e163. - PMC - PubMed
1. Cortes A, Hadler J, Pointon JP, et al. Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci. Nat Genet 2013;45:730–8. - PMC - PubMed
1. Cortes A, Pulit SL, Leo PJ, et al. Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1. Nat Commun 2015;6:7146. - PMC - PubMed
1. Wang Q, Zhou X. Associations of MICA Polymorphisms with Inflammatory Rheumatic Diseases. Open Rheumatol J 2015;9:94–100. - PMC - PubMed

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Imputation-based analysis of MICA alleles in the susceptibility to ankylosing spondylitis

Collaborators

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Imputation-based analysis of MICA alleles in the susceptibility to ankylosing spondylitis

Authors

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Affiliations

Conflict of interest statement

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