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Comparative Study
. 1988 Sep 2;241(4870):1228-9.
doi: 10.1126/science.2970671.

The human laminin receptor is a member of the integrin family of cell adhesion receptors

K R Gehlsen  1 , L Dillner, E Engvall, E Ruoslahti
Affiliations
Comparative Study

The human laminin receptor is a member of the integrin family of cell adhesion receptors

K R Gehlsen et al. Science. .

Erratum in

  • J Cell Biol 1989 Jun;108(6):following 2546
  • Science 1989 Jul 28;245(4916):245

Abstract

A receptor for the adhesive basement membrane protein, laminin, was isolated from human glioblastoma cells by affinity chromatography on laminin. This receptor has a heterodimeric structure similar to that of receptors for other extracellular matrix proteins such as fibronectin and vitronectin. Incorporation of the laminin receptor into liposomal membranes makes it possible for liposomes to attach to surfaces coated with laminin. The receptor liposomes also attached to some extent to surfaces coated with fibronectin, but not with other matrix proteins. These properties identify the laminin receptor as a member of the integrin family of cell adhesion receptors.

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