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Editorial
. 2018 Mar;10(3):1178-1182.
doi: 10.21037/jtd.2018.03.17.

A richer understanding of intratumoral heterogeneity: single-cell genomics put it within reach

Xuetao Li  1   2 , Jun Hou  2   3
Affiliations
Editorial

A richer understanding of intratumoral heterogeneity: single-cell genomics put it within reach

Xuetao Li et al. J Thorac Dis. 2018 Mar.
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Single-cell RNA sequencing is superior to multiregion sampling to explore intratumoral heterogeneity. (A) Shows the analysis of multiregion intratumor heterogeneity (9); (B) depicts the simple workflow of single-cell RNA-seq. It can directly dissociate tumor cells and immune cells from a bulk tumor and overcome the difficulty of multiregion sampling.
See this image and copyright information in PMC

Comment on

  • Tracking the Evolution of Non-Small-Cell Lung Cancer.
    Jamal-Hanjani M, Wilson GA, McGranahan N, Birkbak NJ, Watkins TBK, Veeriah S, Shafi S, Johnson DH, Mitter R, Rosenthal R, Salm M, Horswell S, Escudero M, Matthews N, Rowan A, Chambers T, Moore DA, Turajlic S, Xu H, Lee SM, Forster MD, Ahmad T, Hiley CT, Abbosh C, Falzon M, Borg E, Marafioti T, Lawrence D, Hayward M, Kolvekar S, Panagiotopoulos N, Janes SM, Thakrar R, Ahmed A, Blackhall F, Summers Y, Shah R, Joseph L, Quinn AM, Crosbie PA, Naidu B, Middleton G, Langman G, Trotter S, Nicolson M, Remmen H, Kerr K, Chetty M, Gomersall L, Fennell DA, Nakas A, Rathinam S, Anand G, Khan S, Russell P, Ezhil V, Ismail B, Irvin-Sellers M, Prakash V, Lester JF, Kornaszewska M, Attanoos R, Adams H, Davies H, Dentro S, Taniere P, O'Sullivan B, Lowe HL, Hartley JA, Iles N, Bell H, Ngai Y, Shaw JA, Herrero J, Szallasi Z, Schwarz RF, Stewart A, Quezada SA, Le Quesne J, Van Loo P, Dive C, Hackshaw A, Swanton C; TRACERx Consortium. Jamal-Hanjani M, et al. N Engl J Med. 2017 Jun 1;376(22):2109-2121. doi: 10.1056/NEJMoa1616288. Epub 2017 Apr 26. N Engl J Med. 2017. PMID: 28445112

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