Immune checkpoint blockade in esophageal squamous cell carcinoma: is it ready for prime time?

Eirini Pectasides^{1

2}

Affiliations

¹ Division of Hematology and Oncology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
² Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA.

Editorial

Eirini Pectasides. J Thorac Dis. 2018 Mar.

. 2018 Mar;10(3):1276-1279.

doi: 10.21037/jtd.2018.02.74.

Eirini Pectasides^{1

2}

¹ Division of Hematology and Oncology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
² Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA.

No abstract available

Conflict of interest statement

Conflicts of Interest: The author has no conflicts of interest to declare.

Need for prospective collection of experience and repeated samples in esophageal squamous cell carcinoma.
Hamamoto Y. Hamamoto Y. J Thorac Dis. 2018 Jun;10(Suppl 17):S2086-S2088. doi: 10.21037/jtd.2018.05.37. J Thorac Dis. 2018. PMID: 30023126 Free PMC article. No abstract available.

Nivolumab treatment for oesophageal squamous-cell carcinoma: an open-label, multicentre, phase 2 trial.
Kudo T, Hamamoto Y, Kato K, Ura T, Kojima T, Tsushima T, Hironaka S, Hara H, Satoh T, Iwasa S, Muro K, Yasui H, Minashi K, Yamaguchi K, Ohtsu A, Doki Y, Kitagawa Y. Kudo T, et al. Lancet Oncol. 2017 May;18(5):631-639. doi: 10.1016/S1470-2045(17)30181-X. Epub 2017 Mar 15. Lancet Oncol. 2017. PMID: 28314688 Clinical Trial.

1. Ferlay J, Soerjomataram I, Dikshit R, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer 2015;136:E359-86. 10.1002/ijc.29210 - DOI - PubMed
1. Steevens J, Schouten LJ, Goldbohm RA, et al. Alcohol consumption, cigarette smoking and risk of subtypes of oesophageal and gastric cancer: a prospective cohort study. Gut 2010;59:39-48. 10.1136/gut.2009.191080 - DOI - PubMed
1. Schumacher K, Haensch W, Röefzaad C, et al. Prognostic Significance of Activated CD8+ T Cell Infiltrations within Esophageal Carcinomas. Cancer Res 2001;61:3932-6. - PubMed
1. Cho Y, Miyamoto M, Kato K, et al. CD4+ and CD8+ T cells cooperate to improve prognosis of patients with esophageal squamous cell carcinoma. Cancer Res 2003;63:1555-9. - PubMed
1. Kono K, Kawaida H, Takahashi A, et al. CD4(+)CD25high regulatory T cells increase with tumor stage in patients with gastric and esophageal cancers. Cancer Immunol Immunother 2006;55:1064-71. 10.1007/s00262-005-0092-8 - DOI - PMC - PubMed