Controlling CO2 -Responsive Behaviors of Polymersomes Self-Assembled by Coumarin-Containing Star Polymer via Regulating Its Crosslinking Pattern

Abstract

An oligo(ethylene glycol)-based star polymer of N₂ -(OEG-C)₃ with fluorescent coumarin as hydrophobic end groups and dual tertiary amines as the star center is designed and synthesized. Owing to its amphiphilic nature of N₂ -(OEG-C)₃ , it will self-assemble into hollow vesicles with coumarin groups dispersed in the hydrophobic membrane and exhibits CO₂ -responsive behavior due to the protonation of amine centers with CO₂ . More importantly, coumarin moieties can either form non-crosslinking with γ-cyclodextrin via the 2/1 host-guest inclusion, or covalently photodimerized by 365 nm light, offering a tunable crosslinking pattern in the hydrophobic membrane and thus adjusting its CO₂ -stimulated reorganization and disassembly behaviors of these vesicles in aqueous solution.

Keywords: CO2-responsive; coumarin; crosslinking; star polymers; γ-cyclodextrin.