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. 2018 Apr 30;13(4):e0196452.
doi: 10.1371/journal.pone.0196452. eCollection 2018.

Economic and clinical burden of viral hepatitis in California: A population-based study with longitudinal analysis

Haesuk Park  1 , Donghak Jeong  2 , Pauline Nguyen  2 , Linda Henry  1 , Joseph Hoang  2 , Yoona Kim  2 , Edward Sheen  2 , Mindie H Nguyen  2
Affiliations

Economic and clinical burden of viral hepatitis in California: A population-based study with longitudinal analysis

Haesuk Park et al. PLoS One. .

Erratum in

Abstract

Background: Economic burden of HBV and HCV infection are trending upwards.

Aims: Compare hepatitis B virus (HBV) and hepatitis C virus (HCV) related hospital admission rates, charges, mortality rates, causes of death in a US population-based study.

Methods: Retrospective cohort analysis of HBV and HCV patients from the California Office of Statewide Health Planning and Development (2006-2013) database.

Results: A total of 23,891 HBV and 148,229 HCV patients were identified. Across the 8-year period, the mean increase for all-cause ($1,863 vs $1,388) and liver-related hospitalization charges ($1,175 vs $675) were significantly higher for the HBV cohort compared to the HCV cohort. HBV patients had significantly higher liver-related hospital charges per person per year than HCV patients after controlling for covariates ($123,239 vs $111,837; p = 0.002). Compared to HCV patients, adjusted mortality hazard ratio was slightly lower in HBV patients (relative risk = 0.96; 95% CI 0.94-0.99). The major causes and places of death were different. The three major causes of death for HBV were: other malignant neoplasms (35%), cardiovascular disease/other circulatory disorders (17%), and liver-related disease (15%) whereas for HCV patients were: liver-related disease (22%), other malignant neoplasms (20%), and cardiovascular disease (16%). Regarding the place of death, 53% of HBV patients and 44% of HCV patients died in hospital inpatient, respectively.

Conclusions: HBV patients incurred higher liver-related hospital charges and higher mean increase for all-cause and liver-related hospitalization charges over the 8-year period compared to HCV patients. HBV patients had slightly lower mortality rate and their major causes and places of death were noticeably different from HCV patients.

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Conflict of interest statement

Competing Interests: Mindie Nguyen has received grant support from BMS, Janssen Pharmaceuticals, Gilead Sciences and has served as Advisory board/consulting for Intercept Pharmaceutical, Anylam Pharmaceutical, Gilead Sciences, Dynavax Laboratories and Spring Banks. Haesuk Park has received grant support from Gilead Sciences; Proteus Digital Health. This does not alter our adherence to PLOS ONE policies on sharing data and materials.

Figures

Fig 1
Fig 1. Trends in all-cause hospital charges between 2006 and 2013 in HBV and HCV patients.
A. All-cause hospital charge per patient per year (median). B. All-cause total charges.
See this image and copyright information in PMC

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