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Comment
. 2018 May;4(5):333-335.
doi: 10.1016/j.trecan.2018.02.004. Epub 2018 Mar 7.

Mapping Effector-Phenotype Landscapes in KRAS-Driven Cancers

Peter S Winter  1 , Kris C Wood  2
Affiliations
Comment

Mapping Effector-Phenotype Landscapes in KRAS-Driven Cancers

Peter S Winter et al. Trends Cancer. 2018 May.

Abstract

Oncogenic KRAS can activate numerous effector pathways to drive malignant progression. However, the relationships between specific effectors and oncogenic phenotypes, and the extent to which these relationships vary across heterogeneous tumors, are incompletely understood. Recently in Cell Reports, a team of scientists described an innovative, combinatorial siRNA-based approach to functionally link KRAS effectors and phenotypes in a large panel of cancer cell lines. Central to this work was the identification of two major subtypes of KRAS-mutant cancers with distinct effector landscapes and tractable therapeutic vulnerabilities.

Keywords: KRAS; RNAi; RSK; dependency.

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  • Differential Effector Engagement by Oncogenic KRAS.
    Yuan TL, Amzallag A, Bagni R, Yi M, Afghani S, Burgan W, Fer N, Strathern LA, Powell K, Smith B, Waters AM, Drubin D, Thomson T, Liao R, Greninger P, Stein GT, Murchie E, Cortez E, Egan RK, Procter L, Bess M, Cheng KT, Lee CS, Lee LC, Fellmann C, Stephens R, Luo J, Lowe SW, Benes CH, McCormick F. Yuan TL, et al. Cell Rep. 2018 Feb 13;22(7):1889-1902. doi: 10.1016/j.celrep.2018.01.051. Cell Rep. 2018. PMID: 29444439 Free PMC article.

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