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. 2018 Nov 1:295:93-96.
doi: 10.1016/j.cbi.2018.04.028. Epub 2018 Apr 27.

Potential of siRNA-albumin complex against cancer

Na Liu  1 , Yan-Hua Qi  1 , Chuan-Tao Cheng  2 , Wen Bin Yang  2 , Anshoo Malhotra  3 , Qi Zhou  4
Affiliations

Potential of siRNA-albumin complex against cancer

Na Liu et al. Chem Biol Interact. .

Abstract

RNA interference is a highly specific as well as efficient technology for gene therapy application in molecular oncology. The present study was planned to develop an efficient and stable tumor selective delivery mechanism for siRNA gene therapy for the purpose of both diagnosis as well as therapy. We have used 20 Male wistar rats for the formation of colon cancer model and utilized albumin as carrier molecule for the delivery of siRNA against vascular endothelial growth factor receptor 2 (VEGF R2). The study results confirmed efficient delivery of siRNA at tumor site as confirmed by tagging of siRNA-albumin complex with 99mTC. Moreover, the expression of VEGF also showed decline after efficient delivery of siRNA at tumor site. The study concluded that albumin is an efficient molecule for the efficient delivery of siRNA at tumor sites.

Keywords: (99m)Tc; Albumin; Colon cancer; siRNA.

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