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Review
. 2018 Jun:102:1203-1208.
doi: 10.1016/j.biopha.2018.03.148. Epub 2018 Apr 7.

Tumor-derived extracellular vesicles in angiogenesis

Wei Song  1 , Dong Yan  2 , Tianshu Wei  1 , Qiang Liu  1 , Xia Zhou  3 , Ju Liu  4
Affiliations
Review

Tumor-derived extracellular vesicles in angiogenesis

Wei Song et al. Biomed Pharmacother. 2018 Jun.

Abstract

Angiogenesis is crucial for tumor growth and metastasis. Recent studies revealed that tumor cells promote angiogenesis by secreting extracellular vesicles, which can be captured by endothelial cells. These tumor-derived extracellular vesicles carry microRNAs, long non-coding RNAs, and proteins, which activate pro-angiogenic signaling in endothelial cells. In this review, we will summarize the roles of tumor-derived extracellular vesicles in angiogenesis and the underlying molecular mechanisms.

Keywords: Angiogenesis; Endothelial cells; Extracellular vesicles.

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