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Review
. 1998 May 4;37(8):1044-1070.
doi: 10.1002/(SICI)1521-3773(19980504)37:8<1044::AID-ANIE1044>3.0.CO;2-E.

Modern Variants of the Mannich Reaction

Michael Arend  1 , Bernhard Westermann  1 , Nikolaus Risch  1
Affiliations
Review

Modern Variants of the Mannich Reaction

Michael Arend et al. Angew Chem Int Ed Engl. .

Abstract

Important building blocks for the synthesis of drugs or natural products are found in Mannich bases and their derivatives. Modern variants of the Mannich reaction that expand the potential of the classical intermolecular reaction significantly and enable efficient control of the regioselectivity and stereoselectivity are therefore the topic of intensive research. Intramolecular reactions, in particular as part of domino reaction sequences, often afford astoundingly simple and elegant approaches to complex target compounds.

Keywords: Aminoalkylation; Asymmetric synthesis; Biomimetic synthesis; Domino reactions; Mannich bases.

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