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Review
. 1998 Aug 17;37(15):1986-2012.
doi: 10.1002/(SICI)1521-3773(19980817)37:15<1986::AID-ANIE1986>3.0.CO;2-Z.

Reduction of Carbonyl Compounds with Chiral Oxazaborolidine Catalysts: A New Paradigm for Enantioselective Catalysis and a Powerful New Synthetic Method

Elias J Corey  1 , Christopher J Helal  1
Affiliations
Review

Reduction of Carbonyl Compounds with Chiral Oxazaborolidine Catalysts: A New Paradigm for Enantioselective Catalysis and a Powerful New Synthetic Method

Elias J Corey et al. Angew Chem Int Ed Engl. .

Abstract

High enantioselectivity can be achieved when chiral oxazaborolidines are used as catalysts in the reduction of ketones by borane. In the transition state on the way to the complex chiral compounds, the two reactants are activated and held in close proximity by the catalyst, as shown below.

Keywords: Asymmetric catalysis; Boron; Ketones; Reductions; Total synthesis.

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