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Review
. 1998 Mar 2;37(4):388-401.
doi: 10.1002/(SICI)1521-3773(19980302)37:4<388::AID-ANIE388>3.0.CO;2-V.

The Catalytic Enantioselective Construction of Molecules with Quaternary Carbon Stereocenters

Elias J Corey  1 , Angel Guzman-Perez  1
Affiliations
Review

The Catalytic Enantioselective Construction of Molecules with Quaternary Carbon Stereocenters

Elias J Corey et al. Angew Chem Int Ed Engl. .

Abstract

A long-standing challenge to synthesis can now be met through the use of new and powerful catalytic asymmetric reactions for the assembly of complex chiral molecules with quaternary stereocenters from achiral building blocks. The reaction sequence shown below is just one example discussed in this review.

Keywords: Asymmetric catalysis; Chirality; Enantioselective addition; Quaternary stereocenters; Total synthesis.

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