Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1998 Mar 2;37(4):460-462.
doi: 10.1002/(SICI)1521-3773(19980302)37:4<460::AID-ANIE460>3.0.CO;2-U.

Electron Transfer through DNA in the Course of Radical-Induced Strand Cleavage

Eric Meggers  1 , Dirk Kusch  1 , Martin Spichty  1 , Uta Wille  1 , Bernd Giese  1
Affiliations

Electron Transfer through DNA in the Course of Radical-Induced Strand Cleavage

Eric Meggers et al. Angew Chem Int Ed Engl. .

Abstract

No benefit from base stacking is observed for rates of electron transfer in DNA. This conclusion was drawn from experiments with a new DNA assay in which a radical cationic site, generated by strand cleavage, can be reduced by the guanine bases in the same DNA (the electron transfer is indicated by arrows in the diagram). The distance dependence of this electron transfer step is determined by the chemical yield of the reduction product.

Keywords: DNA cleavage; Electron transfer; Radical ions; Radical reactions.

PubMed Disclaimer

LinkOut - more resources