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. 1999 Jun 14;38(12):1768-1769.
doi: 10.1002/(SICI)1521-3773(19990614)38:12<1768::AID-ANIE1768>3.0.CO;2-6.

A Carbohydrate-Linked Cisplatin Analogue Having Antitumor Activity

Yongsheng Chen  1 , Mary J Heeg  1 , Paul G Braunschweiger  2 , Wenhua Xie  1 , Peng G Wang  1
Affiliations

A Carbohydrate-Linked Cisplatin Analogue Having Antitumor Activity

Yongsheng Chen et al. Angew Chem Int Ed Engl. .

Abstract

An unprotected and intact carbohydrate moiety has been observed for the first time in a transition metal complex. The carbohydrate-linked platinum(II) complex cis-dichloro[(2-β-D-glucopyranosidyl)propane-1,3-diamine]platinum (see picture) is an analogue of cisplatin and exhibits comparable antitumor activity along with increased solubility in water.

Keywords: Antitumor agents; Bioinorganic chemistry; Carbohydrates; N ligands; Platinum.

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