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. 1998 Feb 16;37(3):347-349.
doi: 10.1002/(SICI)1521-3773(19980216)37:3<347::AID-ANIE347>3.0.CO;2-5.

Chemical Synthesis of a Circular Protein Domain: Evidence for Folding-Assisted Cyclization

Julio A Camarero  1 , Joanna Pavel  1 , Tom W Muir  1
Affiliations

Chemical Synthesis of a Circular Protein Domain: Evidence for Folding-Assisted Cyclization

Julio A Camarero et al. Angew Chem Int Ed Engl. .

Abstract

Extremely fast cyclization of the linear polypeptide precursor 1 takes place to form 2. The reaction appears to be assisted by the native fold of 1, which positions the reactive ends in close proximity. The circular topology has no influence on the folding or function of 2.

Keywords: Cyclizations; Peptides; Protein structures; Solid-phase synthesis.

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